Evaluation of Anti Diuretic and Antiuroliathiatic Activity of Methanolic Leaf Extract of Pandanus Fascicularis on Rats

Evaluation of Anti Diuretic and Antiuroliathiatic Activity of Methanolic Leaf Extract of Pandanus Fascicularis on Rats


Shakti Prasanna Sahoo, N. Sucharitha, S. Ramachandran, M.D. Dhanaraju


Abstract

Pandanus fascicularis Lam. (pandanaceae) is claimed as ananti-diuretic by some traditional practitioners. Purpose of the study was to evaluate the anti-diuretic and anti urolithiatic activity of methanolic extract of P.fascicularis. The present study was undertaken to evaluate the anti-diuretic and anti urolithiatic activity in ethylene glycol induced urolithiasis and furosemide induced diuresis. Vasopressin was used as standard for anti-diuretic activity and cystone was used as standard for anti urolithiatic activity. Ethylene glycol feeding resulted in hyperoxaluria as well as increased renal excretion of calcium and oxalate. In furosemide induced diuresis there was increase in urinary output and renal excretion of urinary electrolyte concentration. The methanolic extract of P.fascicularis significantly lowered the stone forming constituents in the kidney of calculogenic rats and also decreased urinary output and urinary volume and urinary electrolyte concentration in furosemide induced diuretic rats. Supplementation with methanolic leaves extract of P.fascicularis significantly reduced the elevated urinary oxalate, showing a regulatory action on endogenous oxalate synthesis. The results indicate that the methanolic leaves extract of P.fascicularis is endowed with anti-diuretic and anti urolithiatic activity.


Keywords

Pandanus fascicularis lam, Antidiuretic, Antiurolithiatic, Methanol extract, Furosemide, Cystone


Cite This Article

Shakti Prasanna Sahoo, N. Sucharitha, S. Ramachandran, M.D. Dhanaraju, Evaluation of Anti Diuretic and Antiuroliathiatic Activity of Methanolic Leaf Extract of Pandanus Fascicularis on Rats, International Journal for Pharmaceutical Research Scholars, 2013, 2(3), 146-150.

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