A Review on Polymers Used in In-Situ Gel Drug Delivery Systems
Shaikh RG, Shah SV, Patel KN, Patel BA, Patel PA
In situ gel drug delivery systems are used in sol form before administration in the body, but once administered, undergo gelation in situ, to form a gel. The formation of gel depends on factors like temperature modulation, pH change, presence of ions and ultraviolet irradiation, electrical sensitivity, enzyme sensitive from which drug get released in a sustained and controlled manner. Typically, aqueous solutions of hydrogels used in biomedical applications are liquid at ambient temperature and gel at physiological temperature. The in situ gel forming polymeric formulations offer several advantages like sustained and prolonged action in comparison to conventional drug delivery systems. From a manufacturing point of view, the production of such devices is less complex and thus lowers the investment and manufacturing cost. This review stresses on the polymeric use of natural polymers and synthetic polymers.
Natural Polymers, Synthetic Polymers, Sol to gel transformation, In-situ, Drug delivery
Cite This Article
Shaikh RG, Shah SV, Patel KN, Patel BA, Patel PA, A Review on Polymers Used in In-Situ Gel Drug Delivery Systems, International Journal for Pharmaceutical Research Scholars, 2012, 1(2), 17-34.