Liquisolid Technique for Enhancement of Dissolution Rate of Ibuprofen
Chuahan PV, Patel HK, Patel BA, Patel KN, Patel PA
Liquisolid system refers to formulations formed by conversion of liquid drugs, drug suspension or drug solution in non-volatile solvents in to non-adherant, free flowing and compressible powder mixtures by blending the solution or suspension with selected carriers and coating materials. The in vitro dissolution property of slightly water soluble Ibuprofen was improved by exploring the potential of Liquisolid system (LS). The in vitro release pattern of Liquisolid compacts and directly compressed tablets were studied using USP-II apparatus. Different Liquisolid compacts were prepared using a mathematical model to calculate the required quantities of powder and liquid ingredients to produce acceptably flowable and compressible admixture. Avicel PH 101, Aerosil and Sodium starch glycolate were employed as carrier, coating material and disintegrant respectively for preparing Liquisolid compacts. The prepared Liquisolid compacts were evaluated for their flow properties such as bulk density, tapped density, angle of repose, Carr’s compressibility index and Hausner’s ratio. The interaction between drug and excipients in prepared Liquisolid compacts were studied by differential scanning calorimetry (DSC) and FT-IR. The drug release rates of Liquisolid compacts were distinctly higher as compared to directly compressed tablets, and marketed Tablet which show significant benefit of Liquisolid compact in increasing wetting properties and surface area of drug available for dissolution. The LS-16 of Liquisolid powder system showed acceptable flowability, Carr’s compressibility index and Hausner’s ratio. The DSC and FT-IR studies conforms the no significant interaction between the drug and excipients used in Liquisolid compacts. From this study it concludes that the Liquisolid technique is a promising alternative for improvement of dissolution property of water-insoluble drugs.
Liquisolid System, Carrier material, Coating material, Non-volatile solvents, Ibuprofen
Cite This Article
Chuahan PV, Patel HK, Patel BA, Patel KN, Patel PA, Liquisolid Technique for Enhancement of Dissolution Rate of Ibuprofen, International Journal for Pharmaceutical Research Scholars, 2012, 1(2), 268-280.