Formulation and Evaluation of Oral Controlled Porosity Osmotic Pump Tablet of Zaltoprofen
Jadav MM, Teraiya SR, Patel KN, Patel BA, Patel PA
Zaltoprofen is a non steroidal anti inflammatory class of drug which has excellent effect on post-surgery or post trauma chronic inflammation of the drug. So, Zaltoprofen may serve as a potent and superior analgesic for the treatment of pain. Zaltoprofen has the dose of 80 mg three times a day which reduce patient compliance. For that in this present study, an attempt has been made to prepare the controlled release CPOP tablet twice a day. An inclusion complex was prepared by kneading method using HP-β-CD in order to increase solubility of the poorly water soluble drug. Then, this complex is used for preparing the tablet with accessorial material. CPOP tablet containing Zaltoprofen were prepared by direct compression method by using various osmotic agent like sodium bicarbonate, sodium chloride, mannitol and potassium carbonate. Cellulose acetate, Sorbitol and Poly Ethylene Glycol 400 were selected for coating materials, and acetone: methanol (65:35) co-solvent was employed as the coating medium with 3% and 5% weight gain. Initially compatibility study was carried out using DSC and FT-IR Spectrometric method. The blend was examined for pre-compression parameters like angle of repose, density, compressibility index and Hausner’s ratio. Formulated tablet also passes the various tablet parameters like hardness, friability, drug content, weight variation. From the result of in-vitro drug release study it was observed that as the amount of osmotic agent increased, amount of drug release increased. Also increased in % weight gain decreased the % drug release. Batch Z4 containing sodium bicarbonate as osmotic agent has shown 98.08% drug release compare to other batches so, accepted as optimized batch. The above optimized batch Z4 was also evaluated by different pharmacokinetic models like Zero order, First order, Higuchi, Korsmeyer Peppas, and Hixson Crowell model. The results of these models have shown that the batch Z4 controls the drug release for 12 hr and follows zero order release kinetics and which is independent of the pH and agitational intensity.
Controlled porosity osmotic pump, Osmotic agent, Zaltoprofen, Cellulose acetate.
Cite This Article
Jadav MM, Teraiya SR, Patel KN, Patel BA, Patel PA, Formulation and Evaluation of Oral Controlled Porosity Osmotic Pump Tablet of Zaltoprofen, International Journal for Pharmaceutical Research Scholars, 2012, 1(2), 254-267.