Formulation and Evaluation of Gastroretentive Drug Delivery System for a Selective Ant diabetic Drug
Shah SV, Lakhani KM, Patel KN, Patel BA, Patel PA
Convenience of administration and patient compliance are gaining significant importance in design of dosage form. Sustained release gastroretentive dosage forms enable prolonged and continuous input of the drug to the upper parts of gastrointestinal tract and improve the bioavailability of medication that is characterized by narrow absorption window. Gastroretentive floating drug delivery systems (GFDDS) of metformin hydrochloride, an antidiabetic drug with an oral bioavailability of only 50% (because of its poor absorption from lower gastrointestinal tract) have been designed and evaluated. Xanthan gum and different grades of Hydroxy propyl methyl cellulose (HPMC) were used as strong gelling agent and sodium bicarbonate as gas generating agent to reduce floating lag time. Tablets were prepared by wet granulation method. Drug-excipients compatibility was studied by FTIR and Differential Scanning Calorimetry (DSC). Floating tablets were evaluated for pre-formulation parameters and for hardness, friability, weight variation, drug content, floating properties and in vitro release pattern. Formulation M3 showed minimum floating lag time and maximum floating time of 12 hours and gave slow and maximum drug release of Metformin HCl spread over 12 hours. The release of drug from the formulation followed zero order kinetics and was governed by non-Fickian diffusion mechanism. The optimized formulation was subjected to stability study.
Metformin hydrochloride, Floating drug delivery system, Xanthan gum, HPMC
Cite This Article
Shah SV, Lakhani KM, Patel KN, Patel BA, Patel PA, Formulation and Evaluation of Gastroretentive Drug Delivery System for a Selective Ant diabetic Drug, International Journal for Pharmaceutical Research Scholars, 2012, 1(2), 178-189.