Synthesis, Spectral Studies and Biological Activities of Quinazolin-4-One Based Some New Pyrazolines Derivatives

Synthesis, Spectral Studies and Biological Activities of Quinazolin-4-One Based Some New Pyrazolines Derivatives


Shah RM, Prajapati NK, Patel PS


Abstract

3-{4-[5-(substitutedphenyl)-4,5-dihydro-pyrazol-3-yl]phenyl}-6-iodo-2-thioxo-2,3-dihydroquinazolin-4-one have been prepared by the refluxation for three hours of 3-{4-[3-substitutedphenyl)prop-2-enoyl]phenyl}-6-iodo-2-thioxo-2,3 dihydroquinazolin -4-one in presence of ethanol & hydrazine hydrate. After Synthesis Compounds Were Characterized by Chemical as Instrumental Methods. Like Elemental, IR and NMR. All the synthesized products were evaluated for their antimicrobial activity. All the compounds were tested for their antibacterial and antifungal activities by broth dilution method.


Keywords

Hydrazine hydrate. Ethanol, IR, NMR, Antimicrobial activity.


Cite This Article

Shah RM, Prajapati NK, Patel PS, Synthesis, Spectral Studies and Biological Activities of Quinazolin-4-One Based Some New Pyrazolines Derivatives, International Journal for Pharmaceutical Research Scholars, 2012, 1(2), 377-381.

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