Synthesis and Antimicrobial Activity of Some New 2-Amino Pyrimidine Derivatives from 1-(3, 5-Dibromo-2-Hydroxy-4 Methyl Phenyl) Ethanone

Synthesis and Antimicrobial Activity of Some New 2-Amino Pyrimidine Derivatives from 1-(3, 5-Dibromo-2-Hydroxy-4 Methyl Phenyl) Ethanone


Pawar MP, Vyas K, Shah NM, Nimavat K


Abstract

The newly synthesized pyrimidine derivatives exhibited moderate to good antimicrobial activity respect to standard drugs. In present investigation, we report the synthesis of 2-amino pyrimidine from chalcones and guanidine hydrochloride using potassium tetr-butoxide as base. These synthesized compounds were characterized on the basis of IR, 1HNMR, Mass spectroscopic data. All synthesized new 2-amino pyrimidine derivatives were screened for antibacterial and antifungal activity against different strains as compare to standard drugs Amoxicillin and Griseofulvin. Compound 3a, 3b, 3d, 3g and 3f were found to be active against selected antibacterial and antifungal strains.


Keywords

2-amino pyridine, 1-(3,5-dibromo-2-hydroxy-4 methyl phenyl) ethanone, chalcone, Antimicrobial Activity.


Cite This Article

Pawar MP, Vyas K, Shah NM, Nimavat K, Synthesis and Antimicrobial Activity of Some New 2-Amino Pyrimidine Derivatives from 1-(3, 5-Dibromo-2-Hydroxy-4 Methyl Phenyl) Ethanone, International Journal for Pharmaceutical Research Scholars, 2012, 1(2), 398-403.

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