Mucoadhesive Buccal Drug Delivery System
Thakkar PP, Soni AM, Chaudhari MJ, Pandya DP, Modi DA
The buccal region of the oral cavity is an attractive target for administration of the drug of choice, particularly in overcoming deficiencies associated with the latter mode of administration. Problems such as high first-pass metabolism and drug degradation in the gastrointestinal environment can be circumvented by administering the drug via the buccal route. Mucoadhesion can be defined as a state in which two components, of which one is of biological origin are held together for extended periods of time by the help of interfacial forces. The mucosa has a buccal dosage forms will be reviewed with an emphasis on bioadhesive polymeric based delivery systems. The mucoadhesive interaction is explained in relation to the structural characteristics of mucosal tissues and the theories & properties of the polymers. To prevent accidental swallowing of drugs adhesive mucosal dosage forms were suggested for oral delivery, which included adhesive tablets, adhesive gels, adhesive patches and many other dosage forms with various combinations of polymers, absorption enhancers. In addition to this, studies have been conducted on the development of controlled or slow release delivery systems for systemic and local therapy of diseases in the oral cavity.
Mucoadhesive; Buccal; Polymers; Retention time; Drug delivery system.
Cite This Article
Thakkar PP, Soni AM, Chaudhari MJ, Pandya DP, Modi DA, Mucoadhesive Buccal Drug Delivery System, International Journal for Pharmaceutical Research Scholars, 2012, 1(2), 360-369.