Formulation & Evaluation of Once Daily Sustained Release Matrix Tablet of Pramipexole Dihydrochloride
Patel NA, Makwana ST, Patel ZP, Solanki SM, Patel MB
The objective of this study was to formulate & evaluate sustained release matrix tablet of Pramipexole Dihydrochloride. Pramipexole Dihydrochloride being highly water soluble drug so, hydrophilic matrices alone are not able to control the drug release for 24 hours. Matrix forming agents like hydroxyl propyl methyl cellulose, rosin & glyceryl behenate in varying concentrations were studied to get the desired sustained release profile over a period of 24 hours. The granules were evaluated for bulk density, angle of repose, compressibility index. Matrix tablets were evaluated for weight variation, hardness, friability & in-vitro release. Release profile of F11 with 15% gum rosin and 25% glyceryl behenate was found to be 99.7% in 24 hrs which was considered as the optimized formulation. Release profile of formulation F11 was found to be very close to theoretical profile of Pramipexole. The drug release followed zero order and found to be diffusion controlled with erosion having high correlation for Higuchi related pattern.
Sustained release, Matrix tablets, Rosin, Glyceryl behenate, Pramipexole dihydrochloride, Higuchi release.
Cite This Article
Patel NA, Makwana ST, Patel ZP, Solanki SM, Patel MB, Formulation & Evaluation of Once Daily Sustained Release Matrix Tablet of Pramipexole Dihydrochloride, International Journal for Pharmaceutical Research Scholars, 2012, 1(2), 370-376.