Use of Combined Techniques of Solubilization for Improving Solubility and Dissolution of Immediate Release Tablet Containing Telmisartan
Jain AJ , Gohel DK, Patel KN, Patel BA, Patel PA
Telmisartan is Angiotensin ΙΙ (AT1) receptor antagonist used in the treatment of hypertension. The drug is practically insoluble in water and insoluble in pH range 3-9, so the rate of dissolution and therefore its bioavailability is less. In this investigation an attempt was made to develop Novel Immediate release solid oral formulations of Telmisartan using Combined Techniques of Solubilization, so Tablet can be prepared using less complicated, less expensive excipients and processes as well as to fulfill all prerequisites for pharmaceutical use. In the study the approach of Combined Techniques of Solubilization used was solid dispersion (SD) based approach were polymers like PVP K 25 and PEG 4000 were used and kneading method was applied For dispersion Preparation and Fluidized Bed Processing was used to prepare Highly Porous and High soluble Granules of Mannitol Coated with Solid Dispersion of Drug and by Using this Granules immediate release tablets were formulated. The experimental batches were designed using fractional factorial design and ANOVA was used for optimization. All the batches were evaluated for Hardness, Friability and In-vitro Disintegration and dissolution time. The Dissolution pattern of optimized formulation were compared with innovator’s product and it was found to be superior to innovator’s product; also they showed pH independent and higher solubility then marketed Product.
Combined Techniques of Solubilization, Fluidized Bed Processing, Solid dispersion.
Cite This Article
Jain AJ , Gohel DK, Patel KN, Patel BA, Patel PA, Use of Combined Techniques of Solubilization for Improving Solubility and Dissolution of Immediate Release Tablet Containing Telmisartan, International Journal for Pharmaceutical Research Scholars, 2012, 1(2), 221-231.