Formulation and Evaluation of Hydrodynamically Balanced Floating Tablet of Biguanide Class Anti-Hypertensive Drug

Formulation and Evaluation of Hydrodynamically Balanced Floating Tablet of Biguanide Class Anti-Hypertensive Drug


Thakur Y, Bhowmick M, Pandey GK, Joshi A, Dubey B


Abstract

Floating sustained release dosage forms present the most of the characteristics of hydrophilic matrices & are known as ‘hydrodynamically balanced systems’ (‘HBS’) since they are able to maintain their low apparent density, while the polymer hydrates & builds a gelled barrier at the outer surface. The drug is released progressively from the swollen matrix, as in the case of conventional hydrophilic matrices. These forms are expected to remain buoyant (3-4 hours) on the gastric contents without affecting the intrinsic rate of emptying because their bulk density is lower than that of the gastric contents. Hydrodynamically balanced tablets of Metformin have been formulated with an approach to increase gastric residence and thereby improve drug bioavailability. An attempt to develop floating tablets of Metformin, using sodium bicarbonate as gas generating agent and HPMC K4M and xanthin gum as hydrophilic polymer by wet granulation method was achieved. The formulated tablets showed compliance for various preformulation studies and various evaluation parameters like hardness, friability, tablet density, floating test, drug content and in vitro release studies.


Keywords

Hydrodynamically Balanced Tablets, Metformin, HPMC K4M, Xanthin gum


Cite This Article

Thakur Y, Bhowmick M, Pandey GK, Joshi A, Dubey B, Formulation and Evaluation of Hydrodynamically Balanced Floating Tablet of Biguanide Class Anti-Hypertensive Drug, International Journal for Pharmaceutical Research Scholars, 2013, 2(4), 21-32.

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