Anti-Hyperglycemic Activity of Tridax Procumbens Root Extract in Streptozotocin Induced Hyperglycemia in Rats
D K B Acharyulu, B Kumaraswamy, Ramachandran S, Dhanraju MD
Tridax procumbens L (asteraceae) have been used, traditionally, for the treatment of various disorders of cancer, wound healing, diabetes, protective activity. The present study was to investigate the possible anti-hyperglycemic activity of Tridax procumbens root [TPR] extracts in streptozotocin induced hyperglycemia in rats. Methanolic extract were administered to the streptozotocin (STZ) [55mg/kg, body weight, intra peritoneal (i.p)] induced hyperglycemia rats for 21 days to study anti-hyperglycemic activity. Blood was collected from retro orbital puncture using capillary tubes. Serum obtained by immediate centrifugation of blood samples using remi ultra cooling centrifuge at 3000 rpm for 15 minutes at room temperature and was directly used for estimating serum glucose. The acute toxicity values of methanol extract after oral administration in mice were found to be 5000 mg/kg. The results concluded that Tridax procumbens methanolic extract (500 mg/kg) have greater anti-hyperglycemic activity than aqueous extract in streptozotocin induced hyperglycemia model and when compared with Glibenclamide treated group. Hence to conclude that methanolic extract of Tridax procumbens root has potent anti- hyperglycemic activity in streptozotocin induced diabetic rats.
Anti-Hyperglycemia, Tridax procumbens root, Streptozotocin, Methanolic Extract
Cite This Article
D K B Acharyulu, B Kumaraswamy, Ramachandran S, Dhanraju MD, Anti-Hyperglycemic Activity of Tridax Procumbens Root Extract in Streptozotocin Induced Hyperglycemia in Rats, International Journal for Pharmaceutical Research Scholars, 2013, 2(3), 192-196.