Synthesis and Characterization of Potato Starch Grafted Poly (2-Hydroxyethyl Methacrylate – Co-Acrylic Acid) Hydrogel for Drug Delivery

Synthesis and Characterization of Potato Starch Grafted Poly (2-Hydroxyethyl Methacrylate – Co-Acrylic Acid) Hydrogel for Drug Delivery


Khedekar RP, Bhitre MJ


Abstract

Hydrogels, three dimensional polymeric networks which swell in water or biological fluids have been explored as a potential carrier for drug(s) in drug delivery systems. The suitability of hydrogel polymer as carrier for drug delivery is attributed to their unique characteristics of imbibing large amounts of fluid, biocompatibility, intelligence of responsiveness to specific stimuli like pH, temperature etc. The potato starch grafted (2-hydroxyethyl methacrylate –co-acrylic acid) hydrogel polymer was synthesized by graft copolymerzation using potato starch (preformed polymer), 2-Hydroxyethyl methacrylate and acrylic acid monomers, Ammonium persulphate (initiator) and N,N-methylene bisacrylamide (crosslinker) with an aim of developing a pH sensitive polymer for drug delivery to GIT. The synthesized polymer was investigated for the effect of change of monomer concentration on the swelling behaviour and characterized by FT-IR, SEM, DSC, Drug loading, swellability and dissolution studies.


Keywords

Hydrogel, Potato starch grafted poly (2-hydroxyethyl methacrylate-co-acrylic acid), Acrylic acid, pH sensitive, 2-hydroxyethyl methacrylate


Cite This Article

Khedekar RP, Bhitre MJ, Synthesis and Characterization of Potato Starch Grafted Poly (2-Hydroxyethyl Methacrylate –Co-Acrylic Acid) Hydrogel for Drug Delivery, International Journal for Pharmaceutical Research Scholars, 2013, 2(3), 197-204.

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