Spherical Crystallization: A Distinctive Practice in Pharmaceutical Processing
Ghodake PP, Bhosale RR, Osmani RA, Harkare BR, Shaikh SM
Developing novel methods to increase the bioavailability of drugs that inherently have poor aqueous solubility is a great challenge to formulate solid dosage form. Mechanical micronization of crystalline drugs and incorporation of surfactants during the crystallization process are the techniques commonly used to improve the bioavailability of poorly soluble drugs. The micronization process alters the flow and compressibility of crystalline powders and cause formulation problems. Addition of surfactant generally led to less significant increase in aqueous solubility. To overcome this problem many researchers developed a spherical crystallization technique that led to improving the flow and direct compressibility of number of microcrystalline drugs. Spherical crystallization is the novel agglomeration technique that can transform directly the fine crystals produced in the crystallization process into a spherical shape. By using this technique, physicochemical properties of pharmaceutical crystals are dramatically improved for pharmaceutical processes.
Crystallization, Micronization, Agglomeration, Spherical crystallization
Cite This Article
Ghodake PP, Bhosale RR, Osmani RA, Harkare BR, Shaikh SM, Spherical Crystallization: A Distinctive Practice in Pharmaceutical Processing, International Journal for Pharmaceutical Research Scholars, 2013, 2(4), 184-192.