Anti-Obesity Effect of Betula Alnoides Bark Extract (Babe) on Plasma Lipids in Male Wistar Rats Fed a Fructose-Rich Diet

Anti-Obesity Effect of Betula Alnoides Bark Extract (Babe) on Plasma Lipids in Male Wistar Rats Fed a Fructose-Rich Diet


Dominic Amal Raj, Malarvili T, Velavan S


Abstract

The anti-obesity effect of Betula alnoides bark extract (BABE) on plasma lipids in male Wistar rats fed a fructose-rich diet (63%w/w) was investigated. Fructose feeding caused significant elevations in the concentrations of plasma triglycerides, phospholipids and free fatty acids. High-density lipoprotein cholesterol (HDL-C) was significantly reduced and very low-density lipoprotein cholesterol (VLDL-C) and low-density lipoprotein cholesterol (LDL–C) were significantly elevated. Activities of lipoprotein lipase (LPL) and lecithin cholesterol acyl transferase (LCAT) in plasma were reduced significantly (p<0.01) as compared to animals fed control diet. Simultaneous oral administration of BABE along with fructose diet mitigated the effects of fructose and these rats showed near-normal levels of the parameters studied. We conclude that BABE normalizes the enzyme activities and plasma lipid alterations in this experimental model. Anti-obesity activity of BABE might be due to phytochemicals as polyphenols.


Keywords

Fructose, Betula alnoides, Obesity, Hyperlipidemia, Lipid Profile


Cite This Article

Dominic Amal Raj, Malarvili T, Velavan S, Anti-Obesity Effect of Betula Alnoides Bark Extract (Babe) on Plasma Lipids in Male Wistar Rats Fed a Fructose-Rich Diet, International Journal for Pharmaceutical Research Scholars, 2013, 2(4), 213-220.

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