Synthesis of 1,2,3,5- Thiatriazines, their Antimicrobial Screening and their Isomerisation into 1,2,3,5-Tetrazines

Synthesis of 1,2,3,5- Thiatriazines, their Antimicrobial Screening and their Isomerisation into 1,2,3,5-Tetrazines


Deshmukh PN, Gaidhane MK, Berad BN


Abstract

Series of new heterocyclic compounds 2H-4-(pyrid-4yl)-5-arylidene / alkylidene-amino-6-phenylimino-5,6-dihydro-1,2,3,5-thiatriazine (8a-f) have been synthesized by the basification of 2H-4-(pyrid-4yl)-5-arylidene / alkylidene – amino – 6- phenylimina-5,6-dihydro-1,2,3,5-thiatriazine hydrochloride (7a-f). The later were synthesized by the interaction of 1-aryl / alkylidene-3-(pyrid-4y) – dihydro formazan (5a-f) with N-phenyl-S-chloroisothiocarbamoyl chloride. The synthesized compounds were further isomerised into 1 phenyl – 4-(pyrid-4yl)-5-aryldene / alkyldene amino – 6-thio-1,2,3,5-tetrazines (9a-f) by using 5 % ethanolic sodium hydroxide. Compound (8) on benzalyation with excess 10 % sodium hydroxide and benzoyl chloride afforted corresponding benzoyl derivatives (10 a-f). The structures of newly synthesized compounds were confirmed on the basis of their elemental IR 1H-NMR and mass spectral analysis. The title compounds were assayed for both antifungal and antibacterial activity against gram positive and gram negative micro-organisms.


Keywords

Synthesis, 1,2,3,5-thiatriazines, Antibacterial and antifungal activity, Isomerization into 1,2,3, 5- tetrazines


Cite This Article

Deshmukh PN, Gaidhane MK, Berad BN, Synthesis of 1,2,3,5- Thiatriazines, their Antimicrobial Screening and their Isomerisation into 1,2,3,5-Tetrazines, International Journal for Pharmaceutical Research Scholars, 2013, 2(4), 244-253.

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