Preparation and Evaluation of Waxes/Fat Microspheres Loaded with Propafenone Hydrochloride for Controlled Release

Preparation and Evaluation of Waxes/Fat Microspheres Loaded with Propafenone Hydrochloride for Controlled Release


D. V. Gowda, Vishnu Datta M, Vikas Kumar Gupta, Siddaramaiah H, Atul Srivastava


Abstract

The objective of this work to prepare and evaluate beeswax microspheres loaded with Propafenone Hydrochloride. It was entrapped into gastro resistant, biodegradable, waxes and fat such as beeswax, cetostearyl alcohol, spermaceti and cetylalcohol microspheres using meltable emulsified dispersion cooling induced solidification technique utilizing a wetting agent. Solid, discrete, reproducible free flowing microspheres were obtained. The yield of the microspheres was up to 92.5%. More than 97.2% of the isolated microspheres were of particle size range 136 to 940 µm. The microspheres had smooth surfaces, with free flowing and good packing properties. Scanning electron microscope confirmed their spherical structures. The drug loaded in waxes and fat microspheres was stable and compatible, as confirmed by DSC and FTIR studies. The release of drug was controlled for more than 8 hours. Intestinal drug release from waxes/ fat microspheres was studied. The release kinetics followed different transport mechanisms. The drug release performance was greatly affected by the materials used in microsphere preparations, which allows absorption in the intestinal tract.


Keywords

Propafenone Hydrochloride, Beeswax, Cetostearyl alcohol, Spermaceti, Cetylalcohol


Cite This Article

D. V. Gowda, Vishnu Datta M, Vikas Kumar Gupta, Siddaramaiah H, Atul Srivastava, Preparation and Evaluation of Waxes/Fat Microspheres Loaded with Propafenone Hydrochloride for Controlled Release, International Journal for Pharmaceutical Research Scholars, 2013, 2(4), 277-285.

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