Protective Effect of Silymarin on L-Arginine Induced Acute Pancreatitis in Rats

Protective Effect of Silymarin on L-Arginine Induced Acute Pancreatitis in Rats


Divya SK, Lakshmi VM, Bhanu V, Devi RP, Devi LA


Abstract

Acute pancreatitis is an inflammatory disorder of the exocrine part of pancreas, which can lead to a systemic inflammatory response syndrome with significant morbidity and mortality in 20% of patients. Involvement of oxidative stress and inflammatory mediators are the major causative factors for the development of acute pancreatitis. Previous studies reported that treatment with α,β amyrin, Pentoxifylline, Alpha lipoic acid, N-acetyl cysteine, Eugenol, Allopurinol, Methyl prednisolone, Melatonin & Selenium have shown protective effect on L-Arginine induced acute pancreatitis by virtue of their anti oxidant & anti-inflammatory properties. Based on these reports, it is presumed that Silymarin, a potential antioxidant & anti-inflammatory agent which might exert a beneficial effect on L-Arginine induced acute pancreatitis in rats. Inflammation of pancreatic gland called pancreatitis (AP) may leads to sever complication and high mortality without treatment. The pathogenesis is not fully understood, however the leukocyte activation, microcirculatory disturbances and oxidative stress are the major constituents of AP. This is characterized by activation of widespread inflammatory cell infiltration, leukocyte and digestive proteases. Reactive oxygen, nitrogen species and various kinds of inflammatory mediators are released in inflammatory process. Previously it was reported that several factors are responsible for the AP, like alcohol, gallstones, hereditary pancreatitis, hypercalcemia, hyperlipidemia, malnutrition, abdominal trauma, penetrating ulcers, malignancy, drugs like steroids, sulfonamides, furosemide, thiazides, infections like mumps, Coxsackie virus, Mycoplasma pneumonia.


Keywords

Acute pancreatitis, L-arginine, Silymarin, Oxidative stress, Inflammation


Cite This Article

Divya SK, Lakshmi VM, Bhanu V, Devi RP, Devi LA, Protective Effect of Silymarin on L-Arginine Induced Acute Pancreatitis in Rats, International Journal for Pharmaceutical Research Scholars, 2013, 2(4), 286-299.

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