Development and Evaluation of Gastro Retentive Ciprofloxacin Floating Tablets

Development and Evaluation of Gastro Retentive Ciprofloxacin Floating Tablets


John Wesley I, Ramasamy C, Anisree GS


Abstract

Gastro retentive drug delivery system is one of the novel drug delivery system have lot of advantages. The various disadvantages of conventional oral dosage form can be successfully rectified by converting to this system. Ciprofloxacin is a broad spectrum antibiotic used commonly for the treatment of lower respiratory tract infection, H. Pylori infection and infectious diarrhea. Gastro retentive drug delivery system of ciprofloxacin fabricated to deliver the drug in a controlled manner. Fabrication done by incorporating drug with mixture of hydroxyl propyl methyl cellulose and sodium alginate as polymers and sodium bicarbonate, as gas forming agent. Various evaluation parameters were undertaken to found out the ideal formulation. The various physico chemical and in-vitro release studies for the system were done. Stability studies also conducted for the ideal formulation and proved for its adequate shelf-life. Pharmacokinetic studies revealed the exact mechanism of drug permeation from the dosage form. Thus, the ideal formulation may be utilized for its controlled release to improve patient compliance.


Keywords

Gastro retentive drug delivery system, Ciprofloxacin, H. pylori, In-vitro studies, Floating tablets, HPMC K4M, Sodium alginate


Cite This Article

John Wesley I, Ramasamy C, Anisree GS, Development and Evaluation of Gastro Retentive Ciprofloxacin Floating Tablets, International Journal for Pharmaceutical Research Scholars, 2013, 2(4), 361-369.

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