Synthesis and Antimicrobial Studies of Schiffs Bases of 2-Carboxy Benzaldehyde and their Azetidinone Derivatives

Synthesis and Antimicrobial Studies of Schiffs Bases of 2-Carboxy Benzaldehyde and their Azetidinone Derivatives


A.V.G.S. Prasad, P. Venkateswara Rao


Abstract

A series of novel Schiffs bases of 2-carboxy benzaldehyde containing azetidinones 4(a-e) were synthesized by reaction of corresponding Schiffs bases 3(a-e) with chloroacetyl chloride in the presence of TEA. The structures of the newly synthesized compounds 4(a-e) were established on the basis of their elemental analyses, IR, 1HNMR, 13 C NMR and mass spectral data. All the title compounds were subjected to in vitro antibacterial testing against four pathogenic strains and antifungal screening against two fungi.


Keywords

Schiffs Base, Carboxy Benzaldehyde, Chloroacetyl Chloride, Antibacterial, Antifungal


Cite This Article

A.V.G.S. Prasad, P. Venkateswara Rao, Synthesis and Antimicrobial Studies of Schiffs Bases of 2-Carboxy Benzaldehyde and their Azetidinone Derivatives, International Journal for Pharmaceutical Research Scholars, 2013, 2(4), 386-389.

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