Bioflavonoids Inhibits Dipeptidyl Peptidase-IV Expressions in Diabetic Rats
Puligilla Shankaraiah, Yellu Narsimha Reddy
The study aim is to investigate the Dipeptidyl peptidase-iv inhibitory activity, antidyslipidemic and anti diabetic effects of the flavonoids (Quercetin, Chrysin & Hesperdin) in alloxan-induced diabetic rats. The effects of orally administered flavonoids (Quercetin, Chrysin & Hesperdin) on serum glucose and antidyslipidemic activity were examined in diabetic control and flavonoids treated diabetic rats. While the activities of the Dipeptidyl peptidase-iv levels, Lipid profiles in the serum were assessed. The flavonoids were administered over a period of 21 days. Results involves the quercetin, chrysin & Hesperdins were significantly (P<0.05) reduced serum glucose, Dipeptidyl peptidase-iv activity and dyslipidemic status in all the flavonoids and pioglitazone treated groups. Conclusions of the present investigation suggests that flavonoids and pioglitazone combination with flavonoids was inhibits Dipeptidyl peptidase-iv activity, dyslipidemic status and hypoglycemic effect in diabetes rats.
DPP-IV, Flavonoids, Blood Glucose, Lipid Profiles
Cite This Article
Puligilla Shankaraiah, Yellu Narsimha Reddy, Bioflavonoids Inhibits Dipeptidyl Peptidase-IV Expressions in Diabetic Rats, International Journal for Pharmaceutical Research Scholars, 2013, 2(4), 390-397.