Evaluation of Anti-Inflammatory and Anti-Arthritic Activity of Rosa Centifolia (Linn.) Flowers in Experimental Rats

Evaluation of Anti-Inflammatory and Anti-Arthritic Activity of Rosa Centifolia (Linn.) Flowers in Experimental Rats


Battiwala Archana J, Shah Chandragopal S, Shiv Kumar


Abstract

To evaluate anti-inflammatory and anti-arthritic activity of aqueous extract of Rosa centifolia (AERC) flowers in male albino rats. The anti-inflammatory activity was evaluated by administering Carrageenan (0.1 ml) into sub plantar region of rat right hind paw and the paw volume was measured at different intervals. The anti-arthritic activity was evaluated by injecting 0.1 ml Freund’s Complete Adjuvant (FCA) into the right hind paw intradermally on day 1 and indomethacin(0.6 mg/kg p.o.) and AERC (400 mg/kg p.o.) treatments were continued up to 14 days. The body weight, rectal temperature, paw volume and ankle diameter were measured on alternate days, whereas RBC and WBC count, hemoglobin, serum Blood urea nitrogen (BUN), albumin, Serum glutamate pyruvate transaminase (SGPT), Serum glutamate oxaloacetate transaminase (SGOT) and Alkaline phosphatase (ALP) levels were estimated on day 14. The radiological studies of right hind paw of rats were also carried out on 14th day. The AERC showed significant reduction in paw volume which was increased by carrageenan. FCA produced loss of body weight, increase in paw volume, ankle diameter, WBC, serum BUN, SGPT, SGOT, ALP and decrease in RBC count, hemoglobin content, serum albumin levels. AERC significant reversed these changes produced by FCA. In conclusion, the aqueous extract of Rosa centifolia (Linn.) flowers possesses significant anti-inflammatory and anti-arthritic activity.


Keywords

Rosa centifolia, Anti-inflammatory, Anti-arthritic, Freund’s Complete Adjuvant, Carrageenan


Cite This Article

Battiwala Archana J, Shah Chandragopal S, Shiv Kumar, Evaluation of Anti-Inflammatory and Anti-Arthritic Activity of Rosa Centifolia (Linn.) Flowers in Experimental Rats, International Journal for Pharmaceutical Research Scholars, 2013, 2(4), 414-426.

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