Method Development and Validation for Estimation of Ornidazole in Dosage Form by Differential UV-Spectrophotometry Method

Method Development and Validation for Estimation of Ornidazole in Dosage Form by Differential UV-Spectrophotometry Method


Bhalodiya HH, Kansagara N, Maru M, Bagada HL


Abstract

Ornidazole is an antiamoebic drug. The drug is commercially available as tablets for oral administration. In the present work two simple, economical, precise and accurate UV spectrophotometric methods have been developed for the estimation of Ornidazole in bulk and pharmaceutical formulation. Differential spectrophotometric method in which λmax=322 nm was selected for analysis of ornidazole. Linearity was observed in the concentration range 8-20μg/ml (r2=0.9992). The methods were validated with respect to linearity, precision and accuracy studies. Recovery studies for Differential spectrophotometry was found to be 100.04%. The methods were found to be simple, precise and accurate and can be employed for routine quality control analysis of ornidazole in bulk as well as from its dosage form.


Keywords

Ornidazole, Differential Spectrophotometry


Cite This Article

Bhalodiya HH, Kansagara N, Maru M, Bagada HL, Method Development and Validation for Estimation of Ornidazole in Dosage Form by Differential UV-Spectrophotometry Method, International Journal for Pharmaceutical Research Scholars, 2013, 2(4), 434-437.

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