Formulation and Evaluation of Eudragit Microspheres Containing Nicorandil

Formulation and Evaluation of Eudragit Microspheres Containing Nicorandil


Keyur S. Patel, Mandev B. Patel


Abstract

The objective of present study was to develop Nicorandil sustained release microspheres by using Eudragit RS 100 and Eudragit RL 100. The Nicorandil loaded Eudragit microspheres were formulated by non aqueous solvent evaporation method and study the effect of different grade of Eudragit and drug: polymer ratio on % Yield, % Entrapment efficiency, particle size and % drug release of microspheres. The Entrapment efficiency was found to be 82.31 ± 1.58% to 91.25 ± 2.54% and particle size range 60.25 ± 1.42 to 92.21 ± 2.32 micrometer. The Batch EU6 showed almost 100 % drug release at 12 hrs. % In vitro drug release was decreased with increasing the drug: polymer ratio. Drug release was high in Eudragit RL 100 microspheres compare to Eudragit RS 100 microspheres. Fickian diffusion was the mode of drug release from Nicorandil loaded Eudragit microspheres formulations.


Keywords

Nicorandil, Eudragit RS 100, Eudragit RL 100, Microspheres


Cite This Article

Patel, K.S., & Patel, M.B. (2014). Formulation and Evaluation of Eudragit Microspheres Containing Nicorandil. International Journal for Pharmaceutical Research Scholars, 3(1), 35-40.

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