Study of the Anti-ulcerogenic Activity of the Methanolic Extracts of Polycarpaea corymbosa lam. (Caryophyllaceae) in Wistar Rats

Study of the Anti-ulcerogenic Activity of the Methanolic Extracts of Polycarpaea corymbosa lam. (Caryophyllaceae) in Wistar Rats


Sindhu Subramanian, Manorama Srirangan


Abstract

Polycarpaea corymbosa Lam. (Caryophyllaceae) is a commonly used plant in Indian traditional system of medicine. In the current study anti-ulcer activity of aerial and root methanol extracts of the plant were investigated using aspirin plus pylorus ligation ulcer model. The extract were also subjected to toxic potential and found to be non-toxic up to 2000 mg/kg dose level. Anti-ulcer activity was evaluated by measuring the ulcer index, gastric content, total and free acidity and pH of gastric fluid in aspirin plus pylorus ligation ulcer model. In this model, Polycarpaea corymbosa at doses of 200 mg/kg produced significant reduction in gastric volume, free acidity and ulcer index compared to control. Therefore, the study concludes that the aerial methanolic extract of Polycarpaea corymbosa possesses potentially useful anti-ulcer activity in aspirin plus pylorus ligated model in rats.


Keywords

Polycarpaea Corymbosa, Anti-Ulcer Activity, Aspirin Plus Pylorus Ligation Ulcer Model


Cite This Article

Subramanian, S., & Srirangan, M. (2014). Study of the Anti-ulcerogenic Activity of the Methanolic Extracts of Polycarpaea corymbosa lam. (Caryophyllaceae) in Wistar Rats. International Journal for Pharmaceutical Research Scholars, 3(1), 126-130.

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