Microwave Assisted Multicomponent Synthesis of Promising Insulin Inhibitor and Mcl-1 Antagonist Thiazolidinone & Pyrazolo Thiazolidine Derivatives
Khot SS, Kapase VS, Kenawade S, Dhongade SR
This work involves synthesis of thiazolidinone derivatives by condensation of various amines with carbon disulfide and chloro acetic acid in presence of NaHCO3 with microwave assisted multicomponent reactions with microwaves (140watts) in a scientific microwave oven, which on further condensation in another MCR with different aromatic aldehydes and hydrazides furnish the 1,3,6-Triaryl-hexahydro-pyrazolo[3,4-d]thiazole-5-thione derivatives [I (a-g)]. Library of such pyrazolo thiazolidine derivatives has been generated and the structures were subjected to PASS for finding their probabilities of being active biologically. QSAR study of the libraries was done to find out most active molecules. 3-Phenyl-2-thioxo-thiazolidin-4-one. (I A) is found most active compound as insulin inhibitor and Mcl-1 antagonist.
Thiazolidinone, Insulin Inhibitor, Pyrazolo Thiazolidine
Cite This Article
Khot, S. S., Kapase, V. S., Kenawade, S., & Dhongade, S. R. (2014). Microwave Assisted Multicomponent Synthesis of Promising Insulin Inhibitor and Mcl-1 Antagonist Thiazolidinone & Pyrazolo Thiazolidine Derivatives. International Journal for Pharmaceutical Research Scholars, 3(1), 363-373.