Synthesis and Evaluation of Ibuprofen Derived Analogs as Potential Anti- Inflammatory Agents

Synthesis and Evaluation of Ibuprofen Derived Analogs as Potential Anti- Inflammatory Agents


Dobhal Y, Gupta R, Kaur I


Abstract

In the present study four ibuprofen analogs having anti-inflammatory potential synthesized with a series of chemical reactions up to final derivative such as 2-(4-sec-butyl-phenyl)-propionic acid-pyridin-2-ylcarbamoylmethyl ester with bio-isosteric concept form ibuprofen. Ibuprofen on refluxing with 2-amino pyridine in chloroacetyl chloride in presence of glacial acetic acid synthesize 2-(4-sec-butyl-phenyl)-propionic acid-pyridin-2-yl-carbamoyl methyl ester, which can be used as a prodrug for ibuprofen. Derivative on treatment with various cycloamino moieties such as morpholine, pyrrolidine, hydrazine hydrate gave compounds. Structure of all these compounds were confirmed on the basis of their analytical and spectral data. The compounds were characterized by IR and elemental analysis. Some of these compounds have shown significant anti-inflammatory activity.


Keywords

Ibuprofen, 2- amino pyridine, Chloroacetyl chloride, Glacial acetic acid, 2-(4-sec-butyl-phenyl)-propionic acid-pyridin-2-yl-carbamoyl methyl ester, Anti-inflammatory activity


Cite This Article

Dobhal, Y., Gupta, R., & Kaur, I. (2014). Synthesis and Evaluation of Ibuprofen Derived Analogs as Potential Anti- Inflammatory Agents. International Journal for Pharmaceutical Research Scholars, 3(1), 437-441.

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