Formulation Development and Evaluation of Alginate-Based Bromhexine Pellets Prepared by Extrusion/Spheronization Containing Hydroxy Propyl Methyl Cellulose
Bashudeb Talukder, Sanzida Pathan, Md. Abdul Motaleb Bhuiya, Kawser Perveen
The study was conducted to develop a stable floating pellet as a multiparticulate system and analysis of the different parameter and in vitro evaluation of the preparation, containing Bromhexine, a mucolytic expectorant. Extrusion/spheronization is a well-known technique which aid in the formation of spherical pellets with regular shape and size, allow the application of a release retarding membrane was utilized in this purpose. Hydroxy propyl methyl cellulose (HPMC) as HPMC K4M and HPMC K100LV and Sodium Alginate polymers at different ratio were incorporated and mixed well with Bromhexine for providing floating properties. Different ratio of these polymers leads to the development of 9 batches. A number of factors such as contraction ratio, moisture content, buoyancy test, swelling index of the formulated preparation and in vitro evaluation at pH 3 were evaluated. Results showed that pellets of all batches are spherical in shape with poor size distribution, remain buoyant in the simulated gastric fluid, water and 0.9 % NaCl solution, whereas Batch CX showed low swelling index (22.65). Scanning Electron Microscopy provides proper idea about pellet morphology and drug distribution in the polymer network. In vitro release study reveal poor release profile up to two hours. Thus stable Bromhexine floating pellet could be formulated by considering the parameter studying in this project work.
Floating pellet, Mucolytic, Extrusion/Spheronization, Polymers, In vitro, Scanning Electron Microscopy
Cite This Article
Bashudeb Talukder, Sanzida Pathan, Md. Abdul Motaleb Bhuiya, Kawser Perveen. (2014). Formulation Development and Evaluation of Alginate-Based Bromhexine Pellets Prepared by Extrusion/Spheronization Containing Hydroxy Propyl Methyl Cellulose. International Journal for Pharmaceutical Research Scholars, 3(1), 506-513.