Synthesis and Anti Proliferative Activity of Isatin Incorporated Quinoxaline Derivatives

Synthesis and Anti Proliferative Activity of Isatin Incorporated Quinoxaline Derivatives


Gautham Naidu, Sravanthi Siliveri, Radhika Tumma, V. Harinadha Babu, B. Madhava Reddy


Abstract

A novel isatin incorporated quinoxaline derivatives have been synthesized by employing hybridization approach and structures were confirmed on the basis of physical and spectral data. In anti-proliferative screening, compounds 5b, 5c and 5d showed promising activity against MDAMB cell line at IC50 values of 4.10, 4.79 and 5.15 µM.


Keywords

Isatin, Quinoxaline Hydrazide, Mannich Reaction, Anti-Proliferative Activity


Cite This Article

Gautham Naidu, Sravanthi Siliveri, Radhika Tumma, V. Harinadha Babu, B. Madhava Reddy. (2014). Synthesis and Anti Proliferative Activity of Isatin Incorporated Quinoxaline Derivatives. International Journal for Pharmaceutical Research Scholars, 3(1), 648-654.

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