Modulated Release of Theophylline from Controlled Release Matrix Tablets

Modulated Release of Theophylline from Controlled Release Matrix Tablets


Faizan Sayeed, Gopal Garg


Abstract

The purpose of the present study was to design, development, formulation and evaluation controlled release matrix tablets for an antiasthmatic drug, Theophylline. Controlled release matrix tablets were prepared using different grades of Hydroxypropyl methylcellulose as matrix former and Povidone as binder. Preformulation study of drug shows that the drug has more solubility in 0.1N HCl hence it is difficult to control the drug release in gastric fluid. But a satisfactory formulation has been developed by using different grades of HPMC (Methocel K4M, Methocel K100 M, Methocel E-50 LV) for Theophylline to extend the drug release for more than 12 hours. The physicochemical compatibility of the drug with polymers was established through DSC spectroscopy. The study indicated that the drug have good compatibility with these polymers. The results of the stability studies suggested that the formulations may provide a minimum shelf life of 2 years.


Keywords

Theophylline, Hydroxypropyl Methylcellulose, Povidone, Controlled Release


Cite This Article

Faizan Sayeed, Sabahuddin Siddique, Gopal Garg, Abdul Sayeed. (2014). Modulated Release of Theophylline from Controlled Release Matrix Tablets. International Journal for Pharmaceutical Research Scholars, 3(1), 817-824.

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