Synthesis and Biological Evaluation of Novel 4-[4-(1H-Benzimidazol-2ylmethoxy) phenyl]-6-(Substituted Phenyl) Pyrimidin-2-Amine as a Potent Antimicrobial Agents

Synthesis and Biological Evaluation of Novel 4-[4-(1H-Benzimidazol-2ylmethoxy) phenyl]-6-(Substituted Phenyl) Pyrimidin-2-Amine as a Potent Antimicrobial Agents


Rajurkar VG, Gaikwad SS, Devdhe SJ, Angadi S


Abstract

A series of potential bioactive compounds, 4-[4-(1H-benzimidazol-2ylmethoxy) phenyl]-6-(substituted phenyl) pyrimidin-2-amine has been synthesized and screened for antibacterial and antifungal activity. Among the series, compound G4g, G4k, G4n, G4d, G4h, G4f, G4l, G4m and G4e, G4g, G4k, G4l were found significant active against E.coli and K.pneumoniae while compounds G4d, G4o, G4e, G4l and G4i, G4j were found significant active against A.niger and S.cerevisiae as compared to standard. The new compounds were characterized by their IR, 1HNMR, and GC mass spectroscopy.


Keywords

Pyrimidine, MIC, Antibacterial, Antifungal


Cite This Article

Rajurkar, V. G., Gaikwad, S. S., Devdhe, S. J., & Angadi, S. (2014). Synthesis and Biological Evaluation of Novel 4-[4-(1H-Benzimidazol-2ylmethoxy) phenyl]-6-(Substituted Phenyl) Pyrimidin-2-Amine as a Potent Antimicrobial Agents. International Journal for Pharmaceutical Research Scholars, 3(1), 872-882.

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