Formulation and Evaluation of Liposomal Topical Gels of Linezolid

Formulation and Evaluation of Liposomal Topical Gels of Linezolid

S. Sharath C Reddy, S. Indira*, Dr. Prathima Srinivas


The objective of the present study was to develop a Linezolid loaded liposomal gel for better anti-bacterial activity by sustaining the drug release and reduces adverse effects. Linezolid is a synthetic antibacterial agent of a new class of Oxazolidinones, which has more effective clinical utility in treatment of infectious diseases compared to Vancomycin, Methicillin. Linezolid liposomes were prepared by thin film hydration technique using soya lecithin, phospholipon 90 H, cholesterol and drug in different weight ratios. They were evaluated for particle size, entrapment efficiency and in vitro drug release. The liposomal dispersion which showed an entrapment of 84.3% and drug release of 61.93 % in 8 hrs was optimized. The optimized formulation was incorporated into gel using Carbopol 934, HPMC K4M and HPMC K15M. Optimized liposomal gel had the drug content of 95.36 and drug release of 49.84% in 8 hrs. Ex vivo studies were performed for the optimized liposomal gel. The flux (Jss) and Permeability coefficient (Kp) was found to be 1320.6 µg/cm2/hr and 0.4402 cm/hr respectively. Stability studies indicated that optimized formulations were stable for a period of 3 months under refrigerated conditions. It was concluded that linezolid loaded liposomal gels were successfully formulated to increase the efficacy and sustain the drug release.


Liposomes, Liposomal Gel, Linezolid, Soya Lecithin, Phospholipon 90 H, Carbopol

Cite This Article

S. Sharath C Reddy, S. Indira, & Dr. Prathima Srinivas. (2014). Formulation and Evaluation of Liposomal Topical Gels of Linezolid. International Journal for Pharmceutical Research Scholars, 3(4), 17-27.

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