Synthesis and Biological Evaluation of Benzoxazole Derivatives as New Anti-Inflammatory Agents

Synthesis and Biological Evaluation of Benzoxazole Derivatives as New Anti-Inflammatory Agents


Anusha P*, J Venkateshwar Rao


Abstract

The main objective of the medicinal chemistry is to synthesize the compounds that show promising activity as therapeutic agents with lower toxicity. Benzoxazole derivatives are very useful compounds with well known biological activity. In the current research work, the title compounds 2-mercapto-N-(substituted arylidine) benzoxazole-5-carbohydrazide derivatives were synthesized by the reaction of Schiff bases of 2-mercapto benzoxazole-5-carbohydrazide with appropriate aromatic aldehydes. The synthesized  compounds  were  confirmed  structurally  by  means  of  IR, 1HNMR, Mass  spectral analysis. Further, the  synthesized  compounds (VIa-VIf)  were screened  for  anti-inflammatory activity  by  using  carrageenan – induced  rat  paw  edema  method. The  results  showed  that, compound  VId   was  significantly  (p<0.001)  reduced the inflammation there  by  showed  a  promising  anti-inflammatory  activity;  whereas  the  compounds  i.e., VIa, VIc, VIe, VIb   moderately  reduced  the  inflammation. Only one compound VIf showed very poor anti-inflammatory activity after one hour of administration.


Keywords

Benzoxazole Derivatives, IR, 1HNMR, Mass Spectroscopy, Anti-inflammatory Activity


Cite This Article

Anusha, P., & J Venkateshwar, Rao. (2014). Synthesis and Biological Evaluation of Benzoxazole Derivatives as New Anti-Inflammatory Agents. International Journal for Pharmaceutical Research Scholars, 3(4), 53-58.

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