Synthesis and Screening of Some New Piperazine Derivatives as Potential Anthelmintic Agents

Synthesis and Screening of Some New Piperazine Derivatives as Potential Anthelmintic Agents


Panchal NB*, Captain AD


Abstract

The purpose of this study is based upon synthesis of a series of 1,4-disubstituted piperazine derivatives through two step reaction. This protocol involves the formation of various mannich base derivatives (N-01 to N-07) through reaction in which microwave synthesis is carried out to prepare 1-phenyl piperazine The second step involves the reaction of 1-phenyl piperazine (N-01 to N-07) with substituted aniline to afford target compounds. (N-01 to N-o7). The structures of target compounds were elucidated from the data of the different spectral methods of analysis. In addition, a mass spectrum, for a representative example, was carried out where the expected fragmentation pattern is in accordance with the structure of the proposed compound. The anthelmintic activity of the synthesized derivatives (N-01 to N-07) was investigated in vitro against Eisenia fetida. All the investigational compounds (N-01 to N-07) and) exhibited promising anthelmintic activity at minimal dose of 5mg/ml in comparison with reference drug Piperazine citrate.


Keywords

1-Phenyl Piperazine, Anthelmintic Activity, Mannich Base, Anthelmintic Activity


Cite This Article

Panchal, N. B., & Captain, A. D. (2015). Synthesis and Screening of Some New Piperazine Derivatives as Potential Anthelmintic Agents, International Journal for Pharmaceutical Research Scholars, 4(1), 26-37.

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