Synthesis of Certain Fluoro Containing Pyrimidine Derivatives
Patel KN, Joshi KA*, Ram HK
Synthesis of a series of 4-(4-(2,6-difluoro-4-nitrophenoxy)phenyl)-N-(substitutedphenyl)-1,2,3,4-tetrahydro-6-methyl-2-oxopyrimidine-5-carboxamide. (4a-j) was achieved from different N-(4-substitutedphenyl)-3-oxobutanamide, 4-(2,6-difluoro-4-nitrophenoxy) benzaldehyde and urea using few drops of conc. hydrochloric acid added and refluxed with ethanol so to the fine yield. The structures of the products were supported by FTIR, 1H NMR and mass spectral data.
4-(2,6-Difluoro-4-Nitrophenoxy) Benzaldehyde; Hydrochloric Acid, Urea Only Refluxed
Cite This Article
Patel, K. N., Joshi, K. A., & Ram, H. K. (2015). Synthesis of Certain Fluoro Containing Pyrimidine Derivatives, International Journal for Pharmaceutical Research Scholars, 4(1), 210-214.