Enhancement of Dissolution of Aceclofenac Film Coated Tablet by Micronisation Technique

Enhancement of Dissolution of Aceclofenac Film Coated Tablet by Micronisation Technique


Soni NM, Trivedi P, Dr. Bhitre MJ


Abstract

Aceclofenac is non-steroidal anti-inflammatory drug with marked anti-inflammatory and analgesic properties. It is indicated for the relief of pain and inflammation in osteoarthritis, rheumatoid arthritis and ankylosing spondylitis. Aceclofenac is BCS class II drug with low solubility and high permeability. Micronization technique is used to increase the solubility and thus dissolution of Aceclofenac. The micronization was done using jet mill micronizer. The initial particle size of drug is 297.33 µ (D90) which was reduced to particle size 121.87 µ (D90) with single micronization, particle size 116.08 µ (D90) with double micronization and 89.23 µ (D90) with triple micronization of drug. It was observed that the solubility and thus dissolution of Aceclofenac was increased in principle media of 6.8 phosphate buffer and discriminating media 4.5 Acetate buffer with single, double and triple micronization. Thus, it can be justified that micronization is one of the good technique for enhancement of solubility of Aceclofenac by reduction of particle size of drug.


Keywords

Aceclofenac, Dissolution, Micronization, Solubility


Cite This Article

Soni NM, Trivedi P, Dr. Bhitre MJ, Enhancement of Dissolution of Aceclofenac Film Coated Tablet by Micronisation Technique, International Journal for Pharmaceutical Research Scholars, 2013, 2(2), 47-52.

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