Formulation and In-Vitro Evaluation of Sustained Release Matrix Tablets of Zolmitriptan
Shivakumar S. Yalameli*, Suresh V. Kulkarni, P. Ashok kumar, Vishwanath Arakeri
The aim of the present research work is to Formulate & in-vitro evaluation studies of sustained release matrix tablets of Zolmitriptan using Locust bean gum, Xanthan gum, HPMC K 100 and Ethyl cellulose. Tablets were prepared by wet granulation method. Zolmitriptan is an anti-migraine drug. Granules were prepared and evaluated for loose bulk density, tapped bulk density, compressibility index and angle of repose. The developed tablets were subjected to various tests for physical parameters such as thickness, hardness, friability, drug content and in vitro release studies. Release kinetics was evaluated by using United States Pharmacopeia USP type II dissolution apparatus. The in vitro dissolution study was carried out for 12 hrs. For first 2hrs in 0.1 N hydrochloric acid (pH 1.2) followed by using phosphate buffer pH 6.8for the remaining 10 hrs. The results of dissolution studies indicated that formulations containing Xanthan gum showed better dissolution than synthetic gums (HPMC K-100, Ethyl cellulose). The dissolution study proved enhanced sustained release when Xanthan gum was used as a matrix forming material.
Sustained release matrix tablet, Zolmitriptan, Locust bean gum, Xanthan gum, HPMC K-100, Ethyl cellulose
Cite This Article
Yalameli SS, Kulkarni SV, Ashok kumar, P. & Arakeri, V. (2015). Formulation and In-Vitro Evaluation of Sustained Release Matrix Tablets of Zolmitriptan, International Journal for Pharmaceutical Research Scholars, 4(4), 78-87.