In Vivo Study of Immunomodulatory Effect of Gmelina arborea Roxb.

In Vivo Study of Immunomodulatory Effect of Gmelina arborea Roxb.


Shaikh HQ*, Dighe VV


Abstract

To study immunomodulatory activity of hydroalcoholic plant extract of Gmelina arborea Roxb. The test animals chosen for the present experiment were Wistar albino rats. The tests carried out were haemagglutination inhibition, delayed type hypersensitivity test, complete blood counts and histopathology (Liver and Spleen). The dried plant powder extract of Gmelina arborea Roxb. was evaluated for immunosuppressive activity using Cyclophosphamide as an immunosuppressive drug and for immunostimulant activity using Septilin as an immunostimulant drug. Humoral immune response was evaluated by withdrawing blood from immunized wistar albino rats for haemagglutination inhibition test. Cell mediated immune response was studied using paw edema test conducted on immunized wistar albino rats. The blood cell counts were evaluated for generalized study of effect of the plant drugs of Gmelina arborea Roxb. Histopathological examination of liver and spleen were evaluated for the effect of plant drug of Gmelina arborea Roxb. on liver and spleen. The results obtained indicates that the plant Gmelina arborea Roxb. Possess immunostimulant activity in vivo.


Keywords

Immunomodulatory activity, Gmelina arborea Roxb., Wistar albino rats, Humoral immune, Cell mediated immune, Blood cell counts, Histopathology


Cite This Article

Shaikh, H. Q., & Dighe, V. V. (2015). In Vivo Study of Immunomodulatory Effect of Gmelina arborea Roxb., International Journal for Pharmaceutical Research Scholars, 4(4), 49-55.

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