A Novel and Efficient Synthesis of Various 7-Hydroxy-9(Furo[2,3-b]Quinolin-2-Yl)6H- Benzo[c]Coumarins and Evaluation of their Antimicrobial Activity

A Novel and Efficient Synthesis of Various 7-Hydroxy-9(Furo[2,3-b]Quinolin-2-Yl)6H- Benzo[c]Coumarins and Evaluation of their Antimicrobial Activity


Dharati S. Patel, D. I. Brahmbhatt*


Abstract

A series of novel 7-hydroxy-9-(furo[2,3-b]quinolin-2-yl)6H-benzo[c]coumarins (3a-l) has been synthesized by reacting various 3-coumarinoyl methyl pyridinium bromide salts (1a-d) with appropriate 2-acetyl-furo[2,3-b]quinoline (2a-c) in the presence of sodium acetate in refluxing acetic acid. All the synthesized compounds were characterized by IR, 1H-NMR, 13C-APT and mass spectral analysis. All the synthesized compounds have been screened for their invitro anti-bacterial and anti-fungal activities. Some of the compounds have been found to be active against some bacterial and fungal pathogens compared to standard drugs. Among the synthesized derivatives, compounds 3c, 3d, 3f and 3j were found to be most efficient members of the series.


Keywords

Furo[2,3-b]quinoline, Benzo[c]coumarin, Antimicrobial activity, Broth dilution method


Cite This Article

Patel, D. S., & Brahmbhatt, D. I. (2017). A Novel and Efficient Synthesis of Various 7-Hydroxy-9(Furo[2,3-b]Quinolin-2-Yl)6H- Benzo[c]Coumarins and Evaluation of their Antimicrobial Activity, International Journal for Pharmaceutical Research Scholars, 6(1), 66-75.

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