Formulation and Evaluation of Okra Fruit Mucilage as a Binder in Paracetamol and Ibuprofen Tablet
Patel VI, Patel HA, Jani M, Shah A, Kumar S, Patel JA
The purpose of this study is to search for cheap and effective natural excipients that can be used as an effective alternative for the formulation of pharmaceutical dosage form. The mucilage from the Okra Fruit (Abelmoschus esculentus) was subjected to Preformulation study for evaluation of its safety and suitability for use as binding agent. The mucilage extracted is devoid of toxicity. Tablets of Lactose were prepared as a control and with 1-5% w/v concentrations of Abelmoschus esculentus mucilage and compared paracetamol, Ibuprofen tablet. The tablets were evaluated for weight variation, hardness,friability and disintegration time according to the USP. Studies indicate that the mucilage of Abelmoschus esculentus may be used as a pharmaceutical adjuvant and as a binding agent at 4 to 5% w/v, depending on its binding ability and the stability of the resulting tablets.
Abelmoschus esculentus, Binding agents, Weight variation, Hardness, Friability, Disintegration time.
Cite This Article
Patel VI, Patel HA, Jani M, Shah A, Kumar S, Patel JA, Formulation and Evaluation of Okra Fruit Mucilage as a Binder in Paracetamol and Ibuprofen Tablet, International Journal for Pharmaceutical Research Scholars, 2012, 1(4), 156-161.