Development and Validation of UV Spectrophotometric Method for Simultaneous Estimation of Cefixime and Linezolid in Combined Dosage Form

Development and Validation of UV Spectrophotometric Method for Simultaneous Estimation of Cefixime and Linezolid in Combined Dosage Form


Patel DP, Goswami K, Patel M


Abstract

Cefixime(CEF) is a cephalosporin class of antibiotic drug and Linezolid(LIN) is a oxazolidinone class of antibiotic drug. This combination of drug is useful in many bacterial diseases. Accurate, precise, rapid and economical method was developed for the simultaneous estimation of Cefixime(CEF) and Linezolid(LIN) in tablet dosage form. Method is based on the simultaneous equations and wavelengths selected for analysis were 289.0nm (λmax of Cefixime) and 257.0 nm (λmax of Linezolid) respectively, in methanol. The linearity was obtained in the concentration range of 5-40μg/ml for Cefixime and 10-30μg/ml for Linezolid. The correlation coefficient of Cefixime and Linezolid were found to be 0.9998 and 0.9998 respectively. The proposed procedure was successfully applied for the simultaneous determination of both drugs in commercial tablet preparation. The results of the analysis have been validated statistically and by recovery studies have confirmed the accuracy of proposed method.


Keywords

Cefixime(CEF), Linezolid(LIN), Simultaneous equations, Ultra-Violet Spectrometric method (UV Spectrometric method).


Cite This Article

Patel DP, Goswami K, Patel M, Development and Validation of UV Spectrophotometric Method for Simultaneous Estimation of Cefixime and Linezolid in Combined Dosage Form, International Journal for Pharmaceutical Research Scholars, 2012, 1(4), 112-118.

Download Google Citation Back