A Novel Approach for Transdermal Drug Delivery as a Liposomes their Progress and Limitations: A Review
Ambarish G, Prajapati SK
The transdermal route of drug delivery has gained great interest of pharmaceutical research, as it circumvents number of problems associated with oral route of drug administration. The uniqueness of this type of drug carrier system lies in the fact that it can accommodate hydrophilic, lipophilic as well as amphiphilic drugs. These drugs find place in different places in the vesicle before they get delivered beneath the skin. Liposomes are micro particulate lipoidal vesicles which are under extensive investigation as drug carriers for improving the delivery of therapeutic agents. Due to new developments in liposome technology, several liposome based drug formulations are currently in clinical trial, and recently some of them have been approved for clinical use. Reformulation of drugs in liposomes has provided an opportunity to enhance the therapeutic indices of various agents mainly through alteration in their bio distribution. This review discusses the potential applications of liposomes in drug delivery with examples of formulations approved for clinical use, and the problems associated with further exploitation of this drug delivery system.
Liposome, Amphotericin B, Drug delivery system, Doxorubicin, Pharmacokinetic.
Cite This Article
Ambarish G, Prajapati SK, A Novel Approach for Transdermal Drug Delivery as a Liposomes their Progress and Limitations: A Review, International Journal for Pharmaceutical Research Scholars, 2012, 1(4), 119-134.