Preparation and Evaluation of Bilayered Buccal Tablet of Glipizide

Author(s)

Sharma, S., Karakambadi, Y., Alam, S.

Author's Affiliation

Abstract

The main objective of the present work was to design a bucco-adhesive bilayered tablet which has potential use in the treatment of Diabetes mellitus. A Bi-layered tablet (Core layer+ Backing layer) containing hypoglycemic agent Glipizide, was formulated. A significant reduction in dose and dosing frequency can be achieved, thereby reducing dose-dependent side effects, patient compliance & prolong the duration of action. Tablets of Glipizide (20 mg) were prepared by direct compression method using bioadhesive polymers like Sodium alginate, Carbopol 934P, HPMC K 100M, Polyvinylpyrrolidone (PVP) in a different ratio. The core layer constituents were Glipizide (20mg), sodium alginate, HPMC K100M, Carbopol 934P, Polyvinylpyrrolidone, Mannitol, Aspartame, Magnesium stearate. Ethyl cellulose acts as backing layer which helps in preventing the back flow of the drug. Buccal tablets were evaluated by different parameters such as thickness, hardness, weight uniformity, and content uniformity, surface pH, ex vivo bioadhesive strength, in vitro drug release, and further studies. The modified in vitro assembly was used to measure the bioadhesive strength of tablets with fresh sheep buccal mucosa as a model tissue. The tablets were evaluated for drug release in pH 6.8 phosphate buffer for 10 hr in standard dissolution apparatus. In order to determine the release kinetics; the data was subjected to Zero order, First order, Korsmeyer and Peppas diffusion model. The mechanism of drug release was found to follow zero order kinetics with regression coefficient value 0.988.

Keywords

Mucoadhesive buccal tablets, bilayered tablets, Glipizide, Carbopol 934P; Sodium alginate, HPMC K 100M, Polyvinylpyrrolidone (PVP), Mannitol, Zero order release

Cite This Article

Sharma, S., Karakambadi, Y., Alam, S. (2017). Preparation and Evaluation of Bilayered Buccal Tablet of Glipizide. International Journal for Pharmaceutical Research Scholars (IJPRS), 6(2), 32-43.