In Vitro Antibacterial Study of Synthesized 3-Quinolinecarbaldehyde through Vilsmeier Haack Cyclisation of N-Arylacetamide and their Hydrazones

In Vitro Antibacterial Study of Synthesized 3-Quinolinecarbaldehyde through Vilsmeier Haack Cyclisation of N-Arylacetamide and their Hydrazones


Sreenivasulu Enamula, Nusrat Shaikh, Khursheed Ahmed*


Abstract

We reported the synthesis and in vitro study of 3-Quinolinecarbaldehyde through Vilsmeier Haack cyclisation of N-arylacetamide and their hydrazones. All the intermediates were confirmed by reported physical constants. The synthesized hydrazones were characterized by IR and NMR. They were further tested for their in vitro antibacterial activity. Results show that the antibacterial activity of the compound increases logarithmically with an increase in concentration. Although all 3 samples show a similar type of inhibition pattern but QSB3 exhibits more antibacterial activity as compared to other samples.


Keywords

3-Quinolinecarbaldehyde, Hydrazones, N-Arylacetamide, Antibacterial Agents


Cite This Article

Sreenivasulu Enamula, Nusrat Shaikh, & Khursheed Ahmed. (2014). In Vitro Antibacterial Study of Synthesized 3-Quinolinecarbaldehyde through Vilsmeier Haack Cyclisation of N-Arylacetamide and their Hydrazones. International Journal for Pharmaceutical Research Scholars, 3(3), 26-32.

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