Studies of Novel Pyrrole and their Biological Studies

Studies of Novel Pyrrole and their Biological Studies


Bhatt JD, Nimavat KS, Vyas KB*


Abstract

2-(1H-benzo[d]imidazol-2-ylthio)-N-arylidene aceto hydrazide (4a-f) was synthesized in good yields by facile condensation of 2-(1H-benzo[d]imidazol-2-ylthio) acetohydrazide(3) with aromatic aldehydes to afford the corresponding. Cyclocondensation of compounds (4a-f) with maleic anhydride yields 1-(2-(1H-benzo[d]imidazol-2-ylthio)acetamido)-5-oxo-2-subsituted phenyl-2,5-dihydro-1H-pyrrole-3-carboxylic acid (5a-f). The structures of these compounds were established on the basis of analytical and spectral data. The synthesized compounds were tested for their antibacterial and antifungal activities.


Keywords

2-(1H-benzo[d]imidazol-2-ylthio) acetohydrazide, Pyrrole, Antibacterial activity and antifungal activity


Cite This Article

Bhatt, J. D., Nimavat, K. S., & Vyas, K. B. (2014). Studies of Novel Pyrrole and their Biological Studies. International Journal for Pharmaceutical Research Scholars, 3(3), 208-213.

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