A Comparative Study between the Effect of Conventional Antilipidaemic Therapy with Statins and Hypolipidaemic Therapy with N – Acetyl Cysteine as Adjunct in Hyperlipidaemic Patients

Author(s)

Joseph, S. D.

Author's Affiliation

Abstract

This is a comparative study between the effect of conventional antilipidaemic therapy with statins and hypolipidaemic therapy with n - acetyl cysteine as adjunct in hyperlipidaemic patients. It was an open controlled randomized study. Totally 82 patients were enrolled for this study. All the patients enrolled for the study were divided in to two groups at random and categorized as Group 1 and Group 2. The baseline serum lipid profile was measured for all the 82 patients and documented on the patient data sheet. Then Group 1 was given atorvastatin 40 mg/day as they were already taking that along with drugs for diabetes and/or hypertension. Group 2 patients additionally received N – Acetylcysteine 600 mg/day orally. Both the groups of patients were monitored for compliance, and for ADRs and side effects. At the end of 6 months the lipid profile of the patients were measured again as the end point. Then the lipid profiles of Group 1 were compared with those of Group 2. The results showed that the reduction in serum total cholesterol, triglyceride, and LDL levels was significant in Group 2. There was no significant effect of therapy on serum LDL, VLDL, and HDL levels between the groups. The study gives a strong evidence for the effect of N – Acetylcysteine, when given as adjunct with conventional lipid lowering therapy, on serum total cholesterol and triglyceride levels in dyslipidaemic patients.

Keywords

Atorvastatin, Cholesterol, N – Acetylcysteine, LDL, Lipid profile

Cite This Article

Joseph, S. D. (2013). A Comparative Study between the Effect of Conventional Antilipidaemic Therapy with Statins and Hypolipidaemic Therapy with N - Acetyl Cysteine as Adjunct in Hyperlipidaemic Patients. International Journal for Pharmaceutical Research Scholars (IJPRS), 2(4), 61-65.