A Review on Mucoadhesive Microspheres as a Novel Drug Delivery System

Author(s)

Thummar, A. V., Kyada, C. R., Kalyanvat, R., Shreevastva, B.

Author's Affiliation

Abstract

The objective of this article is to review the principles underlying the development and evaluation of mucoadhesive microspheres and the research work carried out on these systems.  Mucoadhesion is a topic of current interest in the design of drug delivery systems. Mucoadhesion is commonly defined as the adhesion between two materials, at least one of which is a mucosal surface. Mucoadhesive microspheres may be designed to enable a prolonged residence time at the site of application or absorption and facilitate an intimate contact with the underlying absorption surface and thus contribute to improved and/or better therapeutic performance of drugs. In recent years such mucoadhesive microspheres have been developed for oral, buccal, nasal, ocular, rectal and vaginal routes for either systemic or local effects. This review article aims to provide an overview of the various aspects of mucoadhesion, mucoadhesive materials, factors affecting mucoadhesion, evaluating methods, and various mucoadhesive drug delivery systems.

Keywords

Mucoadhesion, Mechanism of mucoadhesion, Microspheres, Site specific

Cite This Article

Thummar, A. V., Kyada, C. R., Kalyanvat, R., Shreevastva, B. (2013). A Review on Mucoadhesive Microspheres as a Novel Drug Delivery System. International Journal for Pharmaceutical Research Scholars (IJPRS), 2(2), 188-200.