A Scientific Review On: Floating Drug Delivery System (FDDS)

Author(s)

Sutar, F. Y., Gangurde, A. B., Patil, D. M.

Author's Affiliation

Abstract

The several types of Novel drug delivery systems are introduced in the pharmaceutical research and their concepts are used to overcome the certain aspects related to the physical and chemical properties of the drug molecules and the related formulations. Many drugs substances have problem to absorb through the gastrointestinal-tract (GIT) which produces poor bioavailability. Some drugs prominently absorbs from the gastric region due to suitable physicochemical properties Therefore, gastro-retentive drug delivery system (GRDDS) had been developed to improve bioavailability related problems by the prolonging gastric residence time in the upper GIT. One such type of system is floating drug delivery system (FDDS).The aim of the writing this review article on FDDS was to compile the recent literature with special focus on detailed basic mechanism of floatation properties to achieve gastric retention. Conventional oral dosage forms having low bioavailability problems due to their rapid gastric transition from stomach, in case of drugs which are poorly absorb at alkaline pH of intestine. Further drugs which produce their local action in stomach, get rapidly emptied do not get enough residence time in stomach. Hence, the frequency of dose administration in such cases is increased. To avoid these problems several methods have been made to prolong the retention time of drug in stomach. Floating drug delivery system (FDDS) is one of the most important approaches in prolonging the retention time of drug in stomach. FDDS is low-density systems that have sufficient buoyancy to float over the gastric contents and remain buoyant in the stomach for a prolonged period of time without affecting the gastric emptying rate. While the system is floating on the gastric contents, the drug is released slowly at the desired rate which results in a better control of the fluctuations in plasma drug concentration. Several approaches are currently being used to prolong the Gastric Retention Time, including FDDS also known as hydro dynamically balanced systems (HBS), swelling and expanding systems, high-density systems, and other delayed gastric emptying devices. In this review given the detailed outline of various techniques of floating drug delivery system with their advantages over the conventional drug delivery system, limitation and also include the application of these systems.

Keywords

Gastroretentive drug delivery system (GRDDS), Floating drug delivery system (FDDS), Plasma drug concentration, Buoyant, Gastric retention time (GRT)

Cite This Article

Sutar, F. Y., Gangurde, A. B., & Patil, D. M. (2014). A Scientific Review On: Floating Drug Delivery System (FDDS). International Journal for Pharmaceutical Research Scholars (IJPRS), 3(3), 297-314.