Anti-Diabetic Activity of Ethanolic Extract of Lactuca Laevigata (Bl.) Dc. Leaves

Author(s)

Hegde, K., Nongbri, R., Divya, K. V.

Author's Affiliation

Abstract

Based on the ethnobotanical use, the present study has been carried out to evaluate the anti-diabetic activity of ethanolic extract of Lactuca laevigata Blume DC. leaves (EELL) in alloxan and streptozotocin  induced diabetic rats. A dose of 2000 mg/kg of EELL was found to be nontoxic in acute toxicity studies. The 100, 200 and 400 mg/kg, p.o. doses of the extract were subjected to evaluate for the anti-diabetic activity against alloxan (100 mg/kg, i.p) and streptozotocin (50 mg/kg, i.p) induced diabetic rats. EELL treated diabetic rats showed significant (p<0.01) reduction in blood glucose level and increased biochemical parameters such as cholesterol, triglyceride and liver glycogen level, except for HDL and LDL when compared with diabetic control animals. Histopathological studies of pancreas showed the regeneration of β-cells in extract treated diabetic rats, which support the antidiabetic potentials of the extract by preserving the pancreatic islet cells. The present study revealed that the ethanolic extract of Lactuca laevigata Blume leaves was found to be effective against alloxan and streptozotocin induced diabetes and therefore supported the ethnobotanical and traditional belief on antidiabetic effect of the plant Lactuca laevigata.

Keywords

Alloxan, Anti-diabetic activity, Lactuca laevigata, Streptozotocin

Cite This Article

Hegde, K., Nongbri, R., & Divya, K. V. (2014). Anti-Diabetic Activity of Ethanolic Extract of Lactuca Laevigata (Bl.) Dc. Leaves. International Journal for Pharmaceutical Research Scholars (IJPRS), 3(2), 869-875.