Anti-diabetic and Hypolipidemic Effect of Aqueous and Methanolic Root Extracts of Physalis angulata in Streptozotocin (STZ) Induced Diabetic Rats

Author(s)

Reddy, P. A., Vijay, K. R., Reddy, G. V., Reddy, M. K., Reddy, Y. N.

Author's Affiliation

Abstract

The present study was carried out to evaluate the anti-diabetic and hypolipidemic effect of aqueous and methanolic root extracts of Physalis angulata in Streptozotocin (STZ) induced diabetic rats. Aqueous and methanolic root extracts of Physalis angulata were administered orally for 14 days at the dose level of 200 mg/kg and 400 mg/kg to the diabetic rats. The lipid metabolic profiles, like Triglycerides (TG), Total Cholesterol (TC), HDL Cholesterol, VLDL and LDL Cholesterol and serum glutamate pyruvate transaminase (SGPT), serum glutamate oxaloacetate transaminase (SGOT) and oxidative markers like malondialdehyde (MDA), reduced glutathione (GSH), and levels were evaluated in serum. The elevated serum levels of glucose, cholesterol and MDA were normalized in Physalis extracts treated rats, while the HDL cholesterol and GSH levels were increased. These findings reveals that the anti-diabetic and hypolipidemic potential of Physalis angulata root extracts.

Keywords

Physalis Angulata, Diabetes, Lipid profiles, Rats

Cite This Article

Reddy, P. A., Vijay Kumar, R., Reddy, G. V., Reddy, M. K., & Reddy, Y. N. (2014). Anti-diabetic and Hypolipidemic Effect of Aqueous and Methanolic Root Extracts of Physalis angulata in Streptozotocin (STZ) Induced Diabetic Rats. International Journal for Pharmaceutical Research Scholars, 3(1), 402-409.